Adenylyl cyclase 9 is auto-stimulated by its isoform-specific carboxyl terminal domain and equipped with paradigm-switching mechanisms.
This study shows that the C2b domain of AC9 auto-inhibits basal cyclic AMP production and prevents GsR stimulation, with a mutation enabling both increased basal activity and GsR responsiveness.
bioRxiv · Jun 5, 2022Cell Biology