Apelin Stimulation of the Perivascular MuSC Niche Enhances Endogenous Repair in Muscular Dystrophy
E. Le Moal, Y. Liu, J. Collerette-Tremblay, S. Dumontier, J. Boutin, J. Dort, Z. Orfi, J. Michaud, H. Giguere, A. Desroches, F. Vezina, S. Bedard, F. Balg, P. Sarret, M. S. Scott, , C. F. Bentzinger
This study shows that apelin-13 enhances muscle regeneration in dystrophic mice by stimulating endothelial cells in the perivascular niche, improving MuSC function and tissue repair.
bioRxiv · Sep 9, 2022Cell Biology