Homocysteine-induced endoplasmic reticulum stress activates FGF21 via CREBH, resulting in browning and atrophy of white adipose tissue in Bhmt knockout mice.
I. Trujillo-Gonzalez, M. Warrier, E. M. Paules, W. B. Friday, F. Bramlett, H. Kim, K. Zhang
This study shows that BHMT deletion in mice leads to homocysteine-induced ER stress and CREBH activation, increasing FGF21 which causes adipose browning and atrophy.
bioRxiv · Sep 8, 2021 · PreprintCell Biology