Stability Criterion for the Assembly of Hybrid Lipid-Polymer-Nucleic Acid Nanoparticles
J. L. Paris, R. Gaspar, F. Coelho, P. De Beule, B. F. B. Silva
The paper demonstrates that a polycation-DNA core and oppositely charged liposome shell are necessary for stable LPNP formation, with a critical ratio of liposome to polyplex number ensuring stability.
bioRxiv · Feb 6, 2022Biophysics