Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform
J. L. Paris, L. K. Vora, A. M. Perez-Moreno, Y. A. Naser, Q. K. Anjani, J. A. Canas, M. J. Torres, C. Mayorga, R. F. Donnelly
This paper develops a dissolving microneedle array patch containing mesoporous silica nanoparticles of different pore sizes, showing that pore size affects drug loading and release, and that larger pore nanoparticles induce stronger dendritic cell activation.
bioRxiv · Sep 27, 2023Pharmacology & Toxicology