Extracellular RNA induce neutrophil recruitment via endothelial TLR3 during venous thrombosis after vascular injury
M. Y. Najem, R. N. Rys, S. Laurance, F.-R. Bertin, V. Gourdou-Latyszenok, L. Gourhant, L. Le Gall, R. Le Corre, F. Couturaud, M. Blostein, C. A. Lemarie
This study shows that extracellular RNA (eRNA) promotes venous thrombosis by activating TLR3 on endothelial cells, leading to neutrophil recruitment and CXCL5 secretion.
bioRxiv · Jan 18, 2024 · PreprintPhysiology