A weak coupling mechanism mediates the recovery stroke of myosin VI: a free energy simulation and string method analysis
F. E. C. Blanc, A. Houdusse, M. Cecchini
This paper uses free energy simulations and the string method to analyze the recovery stroke of myosin VI, showing that lever-arm re-priming is driven by thermal fluctuations and weakly coupled to ATP hydrolysis.
bioRxiv · Oct 2, 2023 · PreprintBiophysics