R. Covino

Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in situ

The paper uses single-molecule imaging and molecular dynamics simulations to study early MET receptor activation in situ, revealing structural dynamics and a refined dimer model.

IGF2BP1 phosphorylation regulates ribonucleoprotein condensate formation by impairing low-affinity protein and RNA interactions

This study shows that phosphorylation of IGF2BP1 at S181 and Y396 modulates RNP condensate formation by altering low-affinity interactions with RNA and protein partners.

Stress-induced clustering of the UPR sensor IRE1 is driven by disordered regions within its ER lumenal domain

This study shows that IRE1's ER lumenal domain forms dynamic condensates stabilized by membranes and unfolded polypeptides, which are essential for its clustering and signaling.

Unique Amphipathic α-helix Drives Membrane Insertion and Enzymatic Activity of ATG3

The paper identifies an amphipathic α-helix in ATG3 that facilitates membrane insertion and enzymatic activity essential for autophagosome formation.

Cysteine crosslinking in native membranes establishes the transmembrane architecture of Ire1

The paper uses cysteine crosslinking to determine the transmembrane architecture of Ire1 in ER stress signaling, showing an X-shaped configuration independent of stress type.

The evolutionary making of SARS-CoV-2

This study identifies evolutionary innovations in SARS-CoV-2 protein sequences, highlighting functional changes in the spike protein and its furin cleavage site relevant to immune evasion and infection.

Map of SARS-CoV-2 spike epitopes not shielded by glycans.

The paper identifies SARS-CoV-2 spike epitopes not shielded by glycans using molecular dynamics simulations and epitope mapping.

The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1

This study identifies an amphipathic helix in Opi1 that selectively binds phosphatidic acid over phosphatidylserine, revealing lipid headgroup selectivity in membrane recognition.