Succinate accumulation links mitochondrial MnSOD depletion to aberrant nuclear DNA methylation and altered cell fate
K. L. Cramer-Morales, C. D. Heer, K. A. Mapuskar, F. E. Domann
This study shows that MnSOD loss in human erythroleukemia cells leads to succinate accumulation, reduced TET activity, and impaired erythroid differentiation.
bioRxiv · Jun 24, 2020 · PreprintCancer Biology