Author

C. D. Heer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. R. Fehr· 1 shared C. Brenner· 1 shared D. J. Sanderson· 1 shared F. E. Domann· 1 shared K. A. Mapuskar· 1 shared K. L. Cramer-Morales· 1 shared L. S. Voth· 1 shared M. S. Cohen· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. R. Fehr

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2 papers

Recent·Most cited

Succinate accumulation links mitochondrial MnSOD depletion to aberrant nuclear DNA methylation and altered cell fate

K. L. Cramer-Morales, C. D. Heer, K. A. Mapuskar, F. E. Domann

This study shows that MnSOD loss in human erythroleukemia cells leads to succinate accumulation, reduced TET activity, and impaired erythroid differentiation.

bioRxiv · Jun 24, 2020 · PreprintCancer Biology

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

C. D. Heer, D. J. Sanderson, L. S. Voth, Y. M. O. Alhammad, M. S. Schmidt, S. A. J. Trammell, S. Perlman, M. S. Cohen, A. R. Fehr, C. Brenner

This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.

bioRxiv · Apr 17, 2020Microbiology