Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model
F. Frottin, M. Perez-Berlanga, F.-U. Hartl, M. S. Hipp
This study compares the toxicity of C9orf72 DPRs and G4C2 RNA in a cellular model, finding that RNA has a more dominant toxic effect while DPRs add to pathology.
bioRxiv · Sep 14, 2020Biochemistry