Author

F.-U. Hartl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell type annotation· 1 Organism:E. coli· 1

Frequent Co-Authors

G. Krainer· 2 shared I. Saha· 2 shared M. M. Schneider· 2 shared M. S. Hipp· 2 shared Q. A. E. Peter· 2 shared S. Gautam· 2 shared T. W. Herling· 2 shared V. A. Trinkaus· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

G. Krainer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Autophagy preferentially degrades non-fibrillar polyQ aggregates

D. Y. Zhao, F. J. Bauerlein, I. Saha, F.-U. Hartl, W. Baumeister, F. Wilfling

This study shows autophagosomes preferentially degrade non-fibrillar polyQ aggregates by interacting with p62, while amyloid fibrils evade clearance due to their non-deformable structure.

bioRxiv · Aug 8, 2023Cell Biology

Single-molecule digital sizing of proteins in solution

G. Krainer, R. P. B. Jacquat, M. M. Schneider, T. J. Welsh, J. Fan, Q. A. E. Peter, E. A. Andrzejewska, G. Sneideriene, M. A. Czekalska, H. Ausserwoeger, L. Chai, W. E. Arter, K. L. Saar, T. W. Herling, T. M. Franzmann, , T. P. J. Knowles

This paper introduces smMDS, a method for digital sizing of proteins in solution, enabling sensitive and accurate measurement of protein sizes and interactions.

bioRxiv · Jul 12, 2023Biophysics

NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

N. Furthmann, L. Angersbach, V. Bader, A. Blusch, S. Goel, A. Sanchez-Vicente, L. J. Krause, P. Grover, V. A. Trinkaus, E. M. van Well, M. Jaugstetter, K. Tschulik, R. B. Damgaard, C. Saft, G. Ellrichmann, , K. F. Winklhofer

This study identifies a NF-κB-independent role of NEMO in proteostasis by promoting aggrephagy through co-condensation with p62.

bioRxiv · Jun 5, 2023 · PreprintCell Biology

Resolving chaperone-assisted protein folding on the ribosome at the peptide level

T. E. Wales, A. Pajak, A. Roeselova, S. Shivakumaraswamy, S. Howell, F.-U. Hartl, J. R. Engen, D. Balchin

This study uses HDX-MS to map the cotranslational folding pathway of E. coli dihydrofolate reductase, revealing structured intermediates and chaperone interactions on the ribosome.

bioRxiv · Sep 23, 2022Biochemistry

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds

I. Saha, P. Yuste-Checa, M. da Silva Padilha, Q. Guo, R. Körner, H. Holthusen, V. A. Trinkaus, I. Dudanova, R. Fernandez-Busnadiego, W. Baumeister, D. W. Sanders, S. Gautam, M. I. Diamond, F.-U. Hartl, M. S. Hipp

This study shows that the AAA+ chaperone VCP disaggregates Tau fibrils and generates seeding-active Tau as a byproduct, suggesting a role in aggregate removal and spreading in tauopathies.

bioRxiv · Feb 18, 2022Cell Biology

The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds

M. M. Schneider, S. Gautam, T. W. Herling, E. Andrzejwska, G. Krainer, A. M. Miller, Q. A. E. Peter, F. S. Ruggeri, M. Vendruscolo, A. Bracher, C. M. Dobson, F.-U. Hartl, T. Knowles

This study shows the Hsc70-DnaJB1-Apg2 chaperone system removes monomer units directly from α-synuclein fibril ends, reversing aggregation without intermediate fragmentation.

bioRxiv · Nov 2, 2020Biophysics

Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model

F. Frottin, M. Perez-Berlanga, F.-U. Hartl, M. S. Hipp

This study compares the toxicity of C9orf72 DPRs and G4C2 RNA in a cellular model, finding that RNA has a more dominant toxic effect while DPRs add to pathology.

bioRxiv · Sep 14, 2020Biochemistry