CD47-SIRPα controls ADCC killing of primary T cells by PMN through a combination of trogocytosis and NADPH oxidase activation.
F. Gondois-Rey, T. Miller, J. Nunes, D. Olive
This study shows anti-CD47 mAbs induce PMN-mediated T cell killing via trogocytosis and NADPH oxidase activation, highlighting the need to consider PMNs in CD47-SIRP checkpoint therapy.
bioRxiv · Mar 8, 2022Immunology