Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43
J. Garcia Morato, F. Hans, F. von Zweydorf, R. Feederle, S. J. Elsaesser, A. A. Skodras, C. J. Gloeckner, E. Buratti, M. Neumann, P. J. Kahle
This study identifies K136 acetylation as a key modifier of TDP-43's RNA binding and phase separation, leading to pathological aggregation, and shows SIRT1's role in deacetylating and reducing this aggregation.
bioRxiv · May 26, 2020 · PreprintCell Biology