Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missorting
M. P. Schützmann, F. Hasecke, S. Bachmann, M. Zielinski, S. Hänsch, G. F. Schröder, H. Zempel, W. Hoyer
This study shows that endo-lysosomal pH and Aβ concentration drive Aβ oligomer formation, which induces Tau mislocalization and neuronal dysfunction in Alzheimer's disease.
bioRxiv · Jun 28, 2020Biochemistry