Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres
F. Khayat, M. Alshmery, M. Pal, A. W. Oliver, A. Bianchi
The paper identifies a third example of convergent evolution where the TRF2 iDDR motif binds human RAD50 at the same site as the yeast MIN motif, inhibiting MRN nuclease activity at telomeres.
bioRxiv · Mar 25, 2023Biochemistry