Author

A. W. Oliver

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

L. H. Pearl· 2 shared A. Bianchi· 1 shared C. E. L. Fisher· 1 shared F. Khayat· 1 shared F. M. G. Pearl· 1 shared G. Williams· 1 shared I. Campbell Harry· 1 shared J. Baxter· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

L. H. Pearl

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4 papers

Recent·Most cited

Binding of the TRF2 iDDR motif to RAD50 highlights a convergent evolutionary strategy to inactivate MRN at telomeres

F. Khayat, M. Alshmery, M. Pal, A. W. Oliver, A. Bianchi

The paper identifies a third example of convergent evolution where the TRF2 iDDR motif binds human RAD50 at the same site as the yeast MIN motif, inhibiting MRN nuclease activity at telomeres.

bioRxiv · Mar 25, 2023Biochemistry

Cryo-EM structure of the Smc5/6 holo-complex

S. T. Hallett, I. Campbell Harry, P. Schellenberger, L. Zhou, N. B. Cronin, J. Baxter, T. J. Etheridge, J. M. Murray, A. W. Oliver

The paper reports the cryo-EM structure of the budding yeast Smc5/6 holo-complex, revealing its architecture and interactions between subunits.

bioRxiv · Nov 25, 2021Biochemistry

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

X. Chen, Y. Ali, C. E. L. Fisher, R. Arribas-Bosacoma, M. B. Rajasekaran, G. Williams, S. Walker, J. R. Booth, J. J. R. Hudson, S. M. Roe, L. H. Pearl, S. E. Ward, F. M. G. Pearl, A. W. Oliver

The paper identifies an allosteric inhibitor of BLM's ATPase-coupled DNA helicase activity and characterizes its mechanism through crystallographic analysis.

bioRxiv · Nov 30, 2020Biochemistry

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

M. Day, S. L. Parry-Morris, J. Houghton-Gisby, A. W. Oliver, L. H. Pearl

This study determines the crystal structure of CHK1 kinase domain bound to a CLASPIN motif, revealing its role as a scaffold for CHK1 activation by ATR.

bioRxiv · Oct 2, 2020Biochemistry