The comprehensive roadmaps of reprogramming and transformation unveiled antagonistic roles for bHLH transcription factors in the control of cellular plasticity
A. Huyghe, G. Furlan, J. Schroeder, F. Studer, F. Mugnier, L. de Matteo, J. Wang, Y. Yu, N. Rama, B. Gibert, P. Wajda, I. Goddard, N. Gadot, M. Brevet, M. Siouda, , F. Lavial
This study compares the molecular mechanisms of pluripotent reprogramming and malignant transformation, revealing shared and distinct features of cellular plasticity and identifying bHLH transcription factors as key regulators.
bioRxiv · Dec 28, 2020 · PreprintCell Biology