Author

J. M. Polo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Assay:bulk RNA-seq· 5 Organism:mouse· 5 Organism:human· 4 Research Focus:development & morphogenesis· 3 Research Focus:differential expression· 3 Approach:statistical model· 3

Frequent Co-Authors

J. Schroeder· 3 shared J. Chen· 2 shared M. E. Ritchie· 2 shared A. Civitarese· 1 shared A. E. Williamson· 1 shared A. G. Cox· 1 shared A. Hatzipantelis· 1 shared A. Huyghe· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersCell Biology

J. Schroeder

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Metabolism regulates muscle stem cell self-renewal by connecting the microenvironment and histone acetylation

C. H. Ly, J. D. Chung, J. H. Nguyen, L. Tian, J. Schroeder, A. S. Knaupp, S. Su, J. Trieu, T. M. Salmi, D. Zalcenstein, J. S. Jabbari, B. A. Boughton, A. G. Cox, S. H. Naik, J. M. Polo, , J. G. Ryall

The paper identifies how extracellular monosaccharide availability influences muscle stem cell self-renewal through histone acetylation and metabolic signaling.

bioRxiv · Jul 4, 2023 · PreprintCell Biology

Liver-specification of human iPSC-derived endothelial cells transplanted into mouse liver

K. K. Yap, J. Schroeder, Y.-W. Gerrand, A. Kong, A. M. Fox, B. Knowles, S. W. Banting, A. K. Elefanty, E. G. Stanley, G. C. Yeoh, G. P. Lockwood, V. C. Cogger, W. A. Morrison, J. M. Polo, G. M. Mitchell

This study transplants human iPSC-derived endothelial cells into mice to generate LSEC-like cells, identifies key transcription factors and markers for LSEC specification, and provides a model for studying liver endothelial development.

bioRxiv · Jun 28, 2023Cell Biology

Substrate stiffness facilitates improved induced pluripotent stem cell production through modulation of both early and late phases of cell reprogramming

M. M. Chowdhury, S. Samuel Zimmerman, H. Leeson, C. Nefzger, J. C. Mar, A. Laslett, J. M. Polo, E. J. Wolvetang, J. J. Cooper-White

This study shows that medium stiffness substrates enhance iPSC production by improving both early and late reprogramming phases, leading to higher numbers and better quality iPSCs.

bioRxiv · Feb 27, 2023 · PreprintBioengineering

An iTSC-derived placental model of SARS-CoV-2 infection unveils ACE2-dependent susceptibility in syncytiotrophoblasts

J. Chen, J. A. Neil, J. P. Tan, R. Rudraraju, M. Mohenska, Y. B. Sun, G. Sun, Y. Zhou, Y. Li, D. Drew, P. Pymm, W.-H. Tham, F. J. Rossello, G. Nie, X. Liu, , J. M. Polo

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

bioRxiv · Oct 27, 2021 · PreprintCell Biology

Discovery of embryonically derived bipotent endothelial-macrophage progenitor cells in postnatal aorta

A. E. Williamson, S. Liyanage, M. Hassanshahi, M. S. I. Dona, D. Toledo-Flores, D. X. A. Tran, C. Dimasi, N. Schwarz, S. Fernando, T. Salagaras, A. Long, J. Kazenwadel, N. L. Harvey, G. R. Drummond, A. Vinh, , P. J. Psaltis

The paper identifies bipotent endothelial-macrophage progenitor cells in mouse aorta that contribute to postnatal vasculogenesis and macrophage formation.

bioRxiv · Oct 18, 2021 · PreprintCell Biology

CRISPR screens identify gene targets and drug repositioning opportunities at breast cancer risk loci

N. K. Tuano, J. Beesley, M. Manning, W. Shi, L. Malver-Ortega, J. Paynter, D. Black, A. Civitarese, K. McCue, A. Hatzipantelis, K. Hillman, S. Kaufmann, H. Sivakumaran, J. M. Polo, R. Reddel, , J. Rosenbluh

bioRxiv · Sep 7, 2021 · PreprintCancer Biology

The comprehensive roadmaps of reprogramming and transformation unveiled antagonistic roles for bHLH transcription factors in the control of cellular plasticity

A. Huyghe, G. Furlan, J. Schroeder, F. Studer, F. Mugnier, L. de Matteo, J. Wang, Y. Yu, N. Rama, B. Gibert, P. Wajda, I. Goddard, N. Gadot, M. Brevet, M. Siouda, , F. Lavial

This study compares the molecular mechanisms of pluripotent reprogramming and malignant transformation, revealing shared and distinct features of cellular plasticity and identifying bHLH transcription factors as key regulators.

bioRxiv · Dec 28, 2020 · PreprintCell Biology

Xmas ESC: A new female embryonic stem cell system that reveals the BAF complex as a key regulator of the establishment of X chromosome inactivation

A. Keniry, N. Jansz, L. J. Gearing, I. Wanigasuriya, J. Chen, C. M. Nefzger, P. F. Hickey, Q. Gouil, J. Liu, K. Breslin, M. Iminitoff, T. Beck, A. Tapia del Fierro, S. A. Kinkel, P. C. Taberlay, , M. E. Blewitt

The paper introduces a female ESC system called Xmas that identifies the BAF complex as essential for X chromosome inactivation.

bioRxiv · Sep 13, 2019 · PreprintCell Biology