HD mutation results in a dominant negative effect on HTT function
T. L. Laundos, S. Li, E. Cheang, R. De Santis, F. M. Piccolo, A. H. Brivanlou
This study shows that HD mutations cause a dominant negative effect on HTT function by inducing HD-like phenotypes in non-HD cells.
bioRxiv · Jun 26, 2023 · PreprintCell Biology