Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCR?-chain, which highlights the immunopathological aspect of the disease
A. B. M. Astrand, F. N. Hamed, M. Bertolini, A. Rossi, A. Maleki-Dizaji, A. G. Messenger, A. J. McDonagh, R. Tazi-Ahnini
The paper examines Treg cell subsets and TCRβ clonotypes in alopecia areata patients, finding reduced FOXP3+CD39+ Tregs and specific clonotypic differences that suggest potential therapeutic targets.
bioRxiv · Dec 22, 2018Immunology