The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states.
V. Santosh, F. N. Musayev, R. Jaiswal, F. Zarate-Perez, B. Vandewinkel, C. Dierckx, M. Endicott, K. Sharifi, K. Dryden, E. Henckaerts, C. R. Escalante
This study determines the Cryo-EM structure of AAV2 Rep68 bound to ssDNA, revealing its ability to switch between oligomeric states through conformational changes.
bioRxiv · Jun 2, 2020Biochemistry