Author

F. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:electrophysiology· 2 Research Focus:benchmarking· 1 Approach:contrastive learning· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. Barrett-Jolley· 3 shared N. Celik· 2 shared C. A. Staunton· 1 shared C. Dart· 1 shared E. Sayari· 1 shared F. Coenen· 1 shared L. Abdul Kadir· 1 shared R. D. Rainbow· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPhysiology

R. Barrett-Jolley

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Author profile →

3 papers

Recent·Most cited

Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation

F. O'Brien, C. A. Staunton, R. Barrett-Jolley

This study shows that the TRPV4 antagonist GSK2193874 increases tail blood flow in mice across all temperatures, suggesting central rather than peripheral vascular effects on thermoregulation.

bioRxiv · Mar 12, 2021 · PreprintPhysiology

DeepGANnel: Synthesis of fully annotated single molecule patch-clamp data using generative adversarial networks

S. T. M. Ball, N. Celik, E. Sayari, L. Abdul Kadir, F. O'Brien, R. Barrett-Jolley

This paper develops DeepGANnel, a GAN-based method to generate synthetic single molecule patch-clamp data with labels, addressing the lack of large training datasets for automated analysis tools.

bioRxiv · Jun 25, 2020Physiology

Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data

N. Celik, F. O'Brien, S. Brennan, R. D. Rainbow, C. Dart, Y. Zheng, F. Coenen, R. Barrett-Jolley

Deep-Channel uses deep neural networks to automatically detect single-molecule events in patch-clamp data more accurately and faster than traditional methods.

bioRxiv · Nov 22, 2019Physiology