Y. Zheng

Global Marine Cold Seep Metagenomes Reveal Diversity of Taxonomy, Metabolic Function, and Natural Products

The paper analyzes metagenomes from cold seeps to create a database showing microbial diversity and potential natural products.

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Engineered Migrasomes: Harnessing Core Migrasome Machinery and Hypotonic Shock to Develop a Robust and Thermally Stable Vaccine Platform

This study engineers migrasome-like vesicles (eMigrasomes) using hypotonic shock to create a stable, thermally robust vaccine platform that elicits strong immune responses.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples

The paper identifies RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples, linking it to tumor progression and aneuploidy.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Construction and application of a technical platform for determining cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles

This study constructs a technical platform to investigate cell cycle- and autophagy-related nanoparticle accumulation, revealing distinct accumulation patterns in specific cell cycle phases.

Photo-Uncaging Triggers on Self-Blinking to Control Single-Molecule Fluorescence Kinetics for Super-Resolution Imaging

The paper develops a new fluorophore, NOSR, that enables controlled single-molecule blinking for improved super-resolution imaging of microtubules and mitochondrial outer membranes.

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

This study shows that NTS-NTSR2 signaling in white adipocytes regulates food intake by modulating ceramide metabolism and GDF15 production.

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

This study shows that neuritin modulates T cell electrical and metabolic states, influencing immune tolerance and immunity.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Bypassing PELO-mediated ATPase activation of NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases

The paper identifies that pathogenic NLR mutations cause PELO-independent ATPase activation, leading to inflammatory responses and disease, and suggests this as a diagnostic marker.

Linking Structure and Function: Image-Based Virtual Populations of the Retinal Vasculature

This paper develops a framework to generate virtual retinal vasculatures and models their haemodynamics to study the relationship between vascular structure and retinal perfusion.

Genome-wide SNP data reveal recent population structure of Huidobria fruticosa (Loasaceae), a paleo-endemic lineage from the Atacama Desert

The paper uses SNP data from Huidobria fruticosa to show recent population structure shaped by climate change over the last 2 million years in the Atacama Desert.

Manipulating condensation of thermo-sensitive SUF4 protein tunes flowering time in Arabidopsis thaliana

This study shows that temperature-sensitive condensation of SUF4 protein regulates FLC transcription and flowering time in Arabidopsis.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Prdm1 Positively Regulates Liver Group 1 ILCs Cancer Immune Surveillance and Preserves Functional Heterogeneity

This study shows Prdm1 regulates liver cNK cells and ILC1s, affecting cancer metastasis and immune communication, with implications for liver cancer immunotherapy.

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

Graph perceiver network for lung tumor and bronchial premalignant lesion stratification from histopathology

This paper introduces GRAPE-Net, a graph-based model that stratifies bronchial premalignant lesions using histopathology images, showing improved classification accuracy for lung cancer subtypes.

Estradiol propionate reduction of nuclear size in prostate cancer lines lacking DHRS7suggests DHRS7 absence as a biomarker for the effectiveness of estrogen therapy

The paper shows that DHRS7 loss increases nuclear size in prostate cancer cells and that estradiol propionate reduces nuclear size in DHRS7-lacking cells, suggesting DHRS7 as a biomarker for estrogen therapy effectiveness.

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

Haplotype independence contributes to evolvability in the long-term absence of sex in a mite

The paper identifies haplotypic independence as a mechanism enabling long-term survival of an asexual mite species without sex.

Detecting adaptive changes in gene copy number distribution accompanying the human out-of-Africa expansion

The paper investigates whether gene copy number distribution changes in European and Asian populations during the human out-of-Africa expansion are due to demographic factors or adaptive selection.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

A reverse-central-dogma pathway underlies ribosome-antibiotic efficacy and accelerates resistance evolution

This study reveals a reverse-central-dogma pathway by which ribosome antibiotics cause genomic instability and accelerate resistance evolution through transcription-translation coupling disruption.

An Integrated Platform for in vivo Electrophysiology in Spatial Cognition Experiments

The paper introduces a flexible, cost-effective behavioral platform for spatial cognition research with software tools for precise neural event timing and reward delivery.