BiochemistrybioRxiv
Evolution of chalcone isomerase from a non-catalytic ancestor
M. Kaltenbach, J. R. Burke, M. Dindo…·D. S. Tawfik
This study shows chalcone isomerase evolved from a non-catalytic ancestor through four founder mutations with weak epistasis, enabling enantioselective activity.
DOI 10.1038/s41589-018-0042-3