Author

J. P. Noel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:protein folding & dynamics· 5 Assay:structural biology· 5 Organism:E. coli· 3 Organism:plant (other)· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

J. T. Mindrebo· 3 shared M. D. Burkart· 3 shared T. D. Davis· 3 shared A. Chen· 2 shared A. Pabis· 2 shared D. S. Tawfik· 2 shared J. R. Burke· 2 shared M. E. Bowman· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

J. T. Mindrebo

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Author profile →

7 papers

Recent·Most cited

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

bioRxiv · Jul 14, 2023Biophysics

Mechanism-based crosslinking probes capture E. coli ketosynthase FabB in conformationally-distinct catalytic states.

A. Chen, J. T. Mindrebo, T. D. Davis, W. E. Kim, Y. Katsuyama, Z. Jiang, Y. Ohnishi, J. P. Noel, M. D. Burkart

The paper solves crystal structures of E. coli FabB in complex with crosslinked ACPs to elucidate its catalytic mechanism and conformational states.

bioRxiv · Apr 4, 2022 · PreprintBiochemistry

Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases

J. T. Mindrebo, A. Chen, W. E. Kim, R. N. Re, T. D. Davis, J. P. Noel, M. D. Burkart

The paper investigates the gating mechanism of elongating ketosynthases by analyzing structural and functional data from AcpP-FabF complexes.

bioRxiv · Feb 13, 2021Biochemistry

Structural and Dynamic Basis of Molecular Recognition between Acyltransferase and Carrier Protein in E. coli Fatty Acid Synthesis

L. E. Misson, J. T. Mindrebo, T. D. Davis, A. Patel, J. A. McCammon, J. P. Noel, M. D. Burkart

This study determines the structure and dynamics of ACP-AT interactions in E. coli FAS using crystallography, MD simulations, and biochemical analyses, revealing flexible conformations and subdomain motions critical for catalysis.

bioRxiv · May 15, 2020 · PreprintBiochemistry

Algal Neurotoxin Biosynthesis Repurposes the Terpene Cyclase Structural Fold Into an N-prenyltransferase

J. R. Chekan, S. M. K. McKinnie, J. P. Noel, B. S. Moore

The paper reports the structure and function of prenyltransferases from marine algae that repurpose the terpene cyclase fold for N-prenylation of glutamic acid, enabling the biosynthesis of neurotoxins like domoic acid.

bioRxiv · Mar 31, 2020Biochemistry

Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

J. R. Burke, J. J. LaClair, R. N. Philippe, A. Pabis, J. M. Jez, G. A. Cortina, M. Kaltenbach, M. E. Bowman, G. V. Louie, K. B. Woods, A. T. Nelson, D. S. Tawfik, S. C. L. Kamerlin, J. P. Noel

The paper elucidates the catalytic mechanism of chalcone isomerases, showing how an arginine residue activates substrates via Bronsted and Lewis acid interactions, and highlights structural differences between type-1 and type-2 enzymes.

bioRxiv · Oct 30, 2018Biochemistry

Evolution of chalcone isomerase from a non-catalytic ancestor

M. Kaltenbach, J. R. Burke, M. Dindo, A. Pabis, F. S. Munsberg, A. Rabin, S. C. L. Kamerlin, J. P. Noel, D. S. Tawfik

This study shows chalcone isomerase evolved from a non-catalytic ancestor through four founder mutations with weak epistasis, enabling enantioselective activity.

bioRxiv · Aug 10, 2017Biochemistry