A conformational-dependent interdomain redox relay at the core of Protein Disulfide Isomerase activity
E. P. Melo, S. El-Guendouz, C. Correia, F. Teodoro, C. Lopes
This study elucidates the mechanism of PDIA1 activity through an interdomain redox relay, showing how its two active sites cooperate to catalyze disulfide bond formation and resolution.
bioRxiv · Feb 24, 2023Biochemistry