Author

E. P. Melo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Lopes· 2 shared C. Correia· 1 shared C. F. Kaminski· 1 shared D. Ron· 1 shared E. Avezov· 1 shared F. Teodoro· 1 shared I. Mehmeti· 1 shared P. Gollwitzer· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

C. Lopes

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2 papers

Recent·Most cited

A conformational-dependent interdomain redox relay at the core of Protein Disulfide Isomerase activity

E. P. Melo, S. El-Guendouz, C. Correia, F. Teodoro, C. Lopes

This study elucidates the mechanism of PDIA1 activity through an interdomain redox relay, showing how its two active sites cooperate to catalyze disulfide bond formation and resolution.

bioRxiv · Feb 24, 2023Biochemistry

TriPer, an optical probe tuned to the endoplasmic reticulum, tracks H2O2 consumption by glutathione

E. P. Melo, C. Lopes, P. Gollwitzer, S. Lortz, S. Lenzen, I. Mehmeti, C. F. Kaminski, D. Ron, E. Avezov

The paper develops TriPer, an optical probe that detects H2O2 in the ER, revealing glutathione's role in H2O2 turnover during protein folding.

bioRxiv · Feb 3, 2017Cell Biology