Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases
H. Park, Q. Yu, F. V. Hundley, K. Overmyer, L. Serrano, J. A. Paulo, J. C. Paoli, S. Swarup, J. Coon, S. Gygi, W. Harper
This paper develops a method to isolate early endosomes and uses it to study amyloid precursor protein processing by β and γ-secretases in these compartments.
bioRxiv · Mar 31, 2022Cell Biology