Author

S. Gygi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell signaling & trafficking· 7 Assay:proteomics· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Organism:yeast· 3 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

J. A. Paulo· 5 shared D. Kellogg· 2 shared J. Paulo· 2 shared J. Y. Hwang· 2 shared J.-J. Chung· 2 shared T. A. Rapoport· 2 shared A. A. Turanov· 1 shared B. E. Prichard· 1 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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5 shared papersCell Biology

J. A. Paulo

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Author profile →

9 papers

Recent·Most cited

Cell growth and nutrient availability control the mitotic exit signaling network in budding yeast

R. A. Talavera, B. E. Prichard, R. A. Sommer, R. M. Leitao, C. J. Sarabia, S. Hazir, J. A. Paulo, S. Gygi, D. Kellogg

The paper identifies how nutrients regulate the Mitotic Exit Network (MEN) in budding yeast by modulating cell growth and phosphorylation of MEN components.

Journal of Cell Biology · May 9, 2024Peer-reviewedCell Biology

Membrane curvature-generating proteins crucial for autophagosome formation

N. Wang, Y. Shibata, J. A. Paulo, S. Gygi, T. A. Rapoport

This study identifies REEP1 proteins as essential for autophagosome formation by stabilizing the high curvature of the phagophore rim.

bioRxiv · Oct 27, 2022 · PreprintCell Biology

Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases

H. Park, Q. Yu, F. V. Hundley, K. Overmyer, L. Serrano, J. A. Paulo, J. C. Paoli, S. Swarup, J. Coon, S. Gygi, W. Harper

This paper develops a method to isolate early endosomes and uses it to study amyloid precursor protein processing by β and γ-secretases in these compartments.

bioRxiv · Mar 31, 2022Cell Biology

TXNRD3 supports male fertility via the redox control of spermatogenesis

Q. Dou, A. A. Turanov, M. Mariotti, J. Y. Hwang, H. Wang, S.-G. Lee, J. A. Paulo, S. H. Yim, S. Gygi, J.-J. Chung, V. N. Gladyshev

This study shows TXNRD3 is essential for male fertility by regulating redox balance during spermatogenesis, as demonstrated through knockout mice and proteomic analysis.

bioRxiv · Dec 29, 2021 · PreprintBiochemistry

The p97-UBXD8 complex modulates ER-Mitochondria contact sites by modulating membrane lipid saturation and composition

R. Ganji, J. Paulo, Y. Xi, I. Kline, J. Zhu, C. S. Clemen, C. C. Weihl, J. G. Purdy, S. Gygi, M. Raman

This study shows that the p97-UBXD8 complex regulates ER-mitochondria contact sites by modulating membrane lipid saturation and composition, with implications for neurodegenerative diseases.

bioRxiv · Dec 8, 2021 · PreprintCell Biology

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

Z. Ji, H. Li, D. Peterle, J. A. Paulo, S. B. Ficarro, T. E. Wales, J. Marto, S. Gygi, J. R. Engen, T. A. Rapoport

This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.

bioRxiv · Oct 21, 2021Biochemistry

O-GlcNAc regulates gene expression by controlling detained intron splicing

Z.-W. Tan, G. Q. Fei, J. Paulo, S. Bellaousov, S. E. S. Martin, D. Duveau, C. Thomas, S. Gygi, P. Boutz, S. Walker

This study shows O-GlcNAc modification regulates detained intron splicing, affecting gene expression and linking nutrient conditions to transcriptional regulation.

bioRxiv · Mar 27, 2020Cell Biology

EFCAB9 is a pH-Dependent Ca2+ Sensor that Regulates CatSper Channel Activity and Sperm Motility

J. Y. Hwang, N. Mannowetz, Y. Zhang, R. A. Everley, S. Gygi, J. Bewersdorf, P. Lishko, J.-J. Chung

This study identifies EFCAB9 as a pH-dependent Ca2+ sensor that modulates CatSper channel activity and sperm motility through its interaction with CATSPERζ.

bioRxiv · Nov 1, 2018Cell Biology

A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast

J. C. Clarke, N. Dephoure, I. Horecka, S. Gygi, D. Kellogg

The paper identifies a conserved signaling network that responds to sphingolipid delivery to the plasma membrane in budding yeast, linking membrane growth to cell cycle and ribosome biogenesis.

bioRxiv · May 18, 2017Cell Biology