Detecting Somatic Mutations in Rare Clones using Single Cell Multi-Omics
Rhys Gillman, Sonam Dukda, Jerome Samir, Raymond H. Y. Louie, Christopher Carl Goodnow, Fabio Luciano, Mandeep Singh, Matthew A. Field
SCARCE identifies rare somatic mutations in single-cell data by comparing variant frequencies across cell subpopulations, successfully detecting variants in as few as 10 cells.
bioRxiv · Oct 30, 2025 · PreprintBioinformatics