Matthew A. Field

This study identifies clonal IEL expansion and epithelial remodelling in RCD1 using single-cell multi-omics, showing distinct immune and epithelial states compared to ACD.

This study identifies Garcinia brassii metabolites that reduce inflammation and restore gut microbiota balance in IBD, with garcinia biflavonoid 1 and parvifoliol F showing therapeutic potential.

This study shows that malnourishment and microbiome changes enhance the efficacy of a recombinant BCG TB vaccine in mice, linking diet, microbiota, and immune responses to TB protection.

This study shows that pulmonary delivery of ESAT-6-secreting BCG strains improves safety and protection against TB in immunocompromised mice, independent of adaptive immunity.

This paper validates the TARGET-SL framework for predicting genetic events and drug sensitivities in liver cancer using cell lines and patient-derived organoids, showing potential to improve personalized drug screening.

This study identifies parasite-intrinsic transcriptional programs associated with severe P. knowlesi malaria through integrative GWAS, transcriptomic, and eQTL analyses of clinical isolates.

ConsensusMetaDA integrates multiple differential abundance tools to improve sensitivity and specificity in metagenomic analysis by identifying consensus across methods.

SCARCE identifies rare somatic mutations in single-cell data by comparing variant frequencies across cell subpopulations, successfully detecting variants in as few as 10 cells.

The paper analyzes P. knowlesi genomes from Sabah, Malaysia, to identify genetic subpopulations and introgression events linked to environmental factors and host adaptation.

This study shows that CD8+ T cells prevent reactivation of latent Mtb infection after immunosuppression, while B cells are not required for this protection.

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

The paper identifies chromosomal inversions in Acropora kenti with excess mutational load, suggesting they are under balancing selection and may impact adaptation and genetic decline.

The paper uses genomics to assess genetic diversity in koalas and highlights the need for conservation strategies based on threat severity rather than genetic value.

The paper presents a high-quality chromosome-level genome assembly, DNA methylome, and cranial morphology analysis of an Alpine dingo, supporting its status as an archetype for evolutionary studies.

StabilitySort prioritizes pathogenic genetic variants by assessing their impact on protein stability using AlphaFold2 predictions.

The paper presents a desert dingo genome assembly and compares it to domestic dog genomes, identifying structural variants and physiological differences linked to ecological roles.

The paper presents two high-quality Basenji genome assemblies and compares structural variations across three dog breeds, highlighting the impact of reference genome choice on variant detection.

This study uses population genomic approaches to analyze dispersal patterns of Aedes albopictus during a recent invasion in the Torres Strait Islands, revealing gene flow from Papua New Guinea and recent movement between islands.

The paper identifies genetic adaptations in coral holobionts from the Great Barrier Reef's inshore regions linked to Holocene climate change.

consensusDE identifies consistent differential expression across RNA-seq algorithms while integrating RUV correction to improve stability.

The paper shows that pharmacogenetic variants linked to off-target adverse drug reactions are mostly predicted as benign by existing tools.

The paper identifies and removes recurrent false positive variants in single genomes to improve the accuracy of variant calling.

The paper tests TALEN specificity by knocking out three H2A.B genes with a single TALEN pair, demonstrating high specificity for this multi-copy gene family.