Coevolution in Small Heat Shock Protein 1 (HSPB1) is Promoted by Interactions between the Alpha-Crystallin Domain and the Disordered Regions
Vanesa Racigh, Luciana Rodriguez Sawicki, Facundo Nicolas Eric Bravo, Marı́a Silvina Fornasari
This study examines coevolution between the disordered regions and structured Alpha-Crystallin domain of HSPB1, showing that specific residues are evolutionarily constrained to preserve chaperone activity.
PLoS ONE · May 5, 2025Peer-reviewedBiochemistry