Marı́a Silvina Fornasari

The paper identifies transposable elements as a source of intrinsic disorder in human proteins, showing that TE insertions are enriched in disordered regions and their conformational fate depends on their age and TE class.

This study shows HSPB5 binds zinc with high affinity using its disordered N-terminal region, acting as a zinc reservoir under oxidative stress.

This paper identifies a novel Ca2+-binding motif in MICU1 that functions as an early sensor, triggering structural changes that refine its regulatory role in mitochondrial Ca2+ uptake.

This study examines coevolution between the disordered regions and structured Alpha-Crystallin domain of HSPB1, showing that specific residues are evolutionarily constrained to preserve chaperone activity.

The paper uses AlphaFold2 to predict protein-ligand interactions in disordered regions, identifying 'ghost interactions' not captured in crystal structures.

This study shows that AlphaFold2 struggles to predict accurate 3D structures of proteins with conformational epistasis, as seen in the glucocorticoid receptor, but performs well for proteins without such epistasis like the mineralocorticoid receptor.

This study evaluates AlphaFold2's ability to predict ensemble protein conformations and finds it struggles with conformational diversity, with performance worsening as diversity increases.

CoDNaS-RNA is a database that clusters known RNA structures to identify alternative conformers and provides structural and functional annotations.

CardIAP is a web application that automates the analysis of calcium fluorescence imaging data to identify spatio-temporal patterns and extract quantitative information on calcium dynamics.

The paper shows that evolutionary rates of intrinsically disordered proteins correlate with conformational diversity, suggesting that structural constraints from selected conformers influence rate heterogeneity.

The paper compares structural constraints in ordered and disordered protein ensembles, finding similar proportions of constrained sites and long-range contacts.