Luciana Rodriguez Sawicki

This study examines coevolution between the disordered regions and structured Alpha-Crystallin domain of HSPB1, showing that specific residues are evolutionarily constrained to preserve chaperone activity.

The paper uses AlphaFold2 to predict protein-ligand interactions in disordered regions, identifying 'ghost interactions' not captured in crystal structures.

This study shows that AlphaFold2 struggles to predict accurate 3D structures of proteins with conformational epistasis, as seen in the glucocorticoid receptor, but performs well for proteins without such epistasis like the mineralocorticoid receptor.