MFAP5 Drives Elastic Fiber Disorganization to Promote Pulmonary Fibrosis
Zhen Chen, Fanhao Kong, Lixin Huang, Wenze Wu, Ziping Wang, Hanbin Chen, Junting Zhang, Zixin Liu, Jin-Song Bian, Xiaowei Nie
This study identifies MFAP5 as a driver of elastic fiber disorganization in pulmonary fibrosis, showing its role in fibroblast activation and ECM production through TGFβ signaling.
bioRxiv · Dec 12, 2025 · PreprintMolecular Biology