Integrative analysis of spatiotemporal transcriptomics delineates dynamic cell states in squamous tumorigenesis
Varsha Sreekanth, Timur Rusanov, Farah Yousef, Mark A. Sanborn, Su Yeon Yeon, Vijayalakshmi Ananthanarayanan, Olga A. Karginova, Jalees Rehman, Ameen Abdulla Salahudeen
This study uses single-cell and spatial transcriptomics to analyze early stages of squamous cell carcinoma in mice and humans, identifying transcriptomic programs linked to therapeutic resistance.
bioRxiv · Sep 30, 2025 · PreprintCancer Biology