Jalees Rehman

NicheProt: Cell-type-resolved proteomics of tissue compartments

NicheProt enables cell-type and microregion-resolved proteomic analysis by isolating specific cells from defined tissue compartments using 3D microscopy and photobleaching-mediated barcoding.

Ionic Regulation of Mechanosurveillance and Metastasis via the MRTFA/KCNMB1 Axis

This study identifies KCNMB1 and potassium efflux as regulators of cellular stiffness in cancer cells, showing that BK channel activation reduces metastasis and enhances immune cell cytotoxicity.

Regulatory network architecture constrains inflammatory responses in tissue-resident alveolar macrophages

The paper investigates gene regulatory networks in alveolar macrophages, finding that tissue-resident macrophages have more restrained inflammatory responses due to a stabilizing network involving PU.1 and CEBP/β.

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation

The paper identifies a titin missense variant linked to atrial fibrillation through altered ion channel function and calcium homeostasis in human iPSC-derived atrial cardiomyocytes.

Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation

This study identifies PRPS-PRPSAP complexes as regulators of histone chaperone interactions, linking nucleotide biosynthesis to chromatin assembly.

scRegulate: Single-Cell Regulatory-Embedded Variational Inference of Transcription Factor Activity from Gene Expression

scRegulate infers transcription factor activity and gene regulatory networks from scRNA-seq data using a deep learning framework, showing improved accuracy and efficiency over existing methods.

Integrative analysis of spatiotemporal transcriptomics delineates dynamic cell states in squamous tumorigenesis

This study uses single-cell and spatial transcriptomics to analyze early stages of squamous cell carcinoma in mice and humans, identifying transcriptomic programs linked to therapeutic resistance.

Persistent Immune Dysregulation during Post-Acute Sequelae of COVID-19 is Manifested in Antibodies Targeting Envelope and Nucleocapsid Proteins

This study examines immune dysregulation in Long COVID patients, finding persistent elevated anti-envelope and nucleocapsid antibodies and increased autoantibodies over six months.

Local optogenetic control of genome editing and tumorigenesis in vivo using wireless implantable optoelectronics

This study develops a wireless optogenetic system to control genome editing and tumorigenesis in mice by using light-regulated recombinase and implantable devices.

Inhibition of β-catenin signaling by Amyloid-β in endothelial cells impairs vascular barrier integrity

This study shows that Amyloid-β inhibits β-catenin signaling in endothelial cells, reducing BBB integrity and contributing to Alzheimer's Disease progression.

Matrimeres are systemic nanoscale mediators of tissue integrity and function

The paper identifies matrimeres as nanoscale mediators of tissue integrity, showing they can restore vascular integrity after injury and are reconstituted from fibronectin, DNA, and acidic conditions.

Engineered Wnt7a ligands rescue blood brain barrier and neurobehavioral deficits in a mouse model of COVID-19

This study shows engineered Wnt7a ligands improve blood brain barrier and neurobehavioral deficits in a SARS-CoV-2 infected mouse model.

Systematic temporal analysis of peripheral blood transcriptomes using TrendCatcher identifies early and persistent neutrophil activation as a hallmark of severe COVID-19