H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma
Tima Shamekhi, Bijun Zeng, Claire Xin Sun, Paul M Daniel, Terry C.C. Lim Kam Sian, Gabriel Gonçalves, Grace Huang, Farnaz Fahimi, Nivedhitha Selvakumar, Erwin Tanuwidjaya, Isaac B. Woodhouse, Bettina Kritzer, Ralf B. Schittenhelm, Roberta Mazzieri, Jason E. Cain, , Pouya Faridi
This study identifies six immunogenic peptides in diffuse midline glioma (DMG) linked to the H3K27M mutation, offering potential targets for T cell-based immunotherapy.
bioRxiv · Apr 7, 2025 · PreprintCancer Biology