The paper compiles HLA typing and expression data for 287 pediatric cancer cell lines to support immunotherapy research and personalized treatment development.

iScience · Oct 29, 2025Peer-reviewedCancer Biology

H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma

Tima Shamekhi, Bijun Zeng, Claire Xin Sun, Paul M Daniel, Terry C.C. Lim Kam Sian, Gabriel Gonçalves, Grace Huang, Farnaz Fahimi, Nivedhitha Selvakumar, Erwin Tanuwidjaya, Isaac B. Woodhouse, Bettina Kritzer, Ralf B. Schittenhelm, Roberta Mazzieri, Jason E. Cain, , Pouya Faridi

This study identifies six immunogenic peptides in diffuse midline glioma (DMG) linked to the H3K27M mutation, offering potential targets for T cell-based immunotherapy.

bioRxiv · Apr 7, 2025 · PreprintCancer Biology

HLA binding of self-peptides is biased towards proteins with specific molecular functions

Vadim K Karnaukhov, Wayne Paes, Isaac B. Woodhouse, Thomas Partridge, Annalisa Nicastri, Simon Brackenridge, D. N. Scherbinin, Dmitriy M. Chudakov, Ivan V. Zvyagin, Nicola Ternette, Hashem Koohy, Persephone Borrow, Mikhail Shugay

The paper shows HLA alleles preferentially present peptides from proteins with specific molecular functions, linking these preferences to HLA allele differences and disease susceptibility.

bioRxiv · Feb 16, 2021 · PreprintBioinformatics

CiiiDER: a new tool for predicting and analysing transcription factor binding sites

Linden J. Gearing, Helen E. Cumming, Ross Chapman, Alexander M. Finkel, Isaac B. Woodhouse, Kevin Luu, Jodee A. Gould, Samuel C. Forster, Paul J. Hertzog

CiiiDER predicts and analyses transcription factor binding sites using experimentally verified motifs, offering enrichment analysis to identify regulatory pathways.

PLoS ONE · Sep 4, 2019Peer-reviewedBioinformatics