A RIF1/KAP1-based toggle switch stabilises the identities of the inactive and active X chromosomes during X inactivation
Elin Enervald, Lynn Marie Powell, Lora Boteva, Rossana Foti, Nerea Blanes Ruiz, Gözde Kibar, Agnieszka Piszczek, Fatima M. Cavaleri, Martin Vingron, Andrea Cerase, Sara B.C. Buonomo
The paper identifies RIF1 and KAP1 as key factors in establishing an asymmetric state during X inactivation by coordinating Tsix and Xist expression.
The EMBO Journal · Nov 17, 2021Peer-reviewedMolecular Biology