Sara B.C. Buonomo

RIF1 orchestrates a multi-step restoration of post-replicative H3K9me3

This study identifies RIF1's role in restoring H3K9me3 post-replication by facilitating SUV39H1, HP1, and PP1 recruitment and restraining Aurora kinase activity.

Supervised and unsupervised deep learning-based approaches for studying DNA replication spatiotemporal dynamics

This study uses supervised and unsupervised deep learning to analyze DNA replication dynamics in mouse cells, identifying altered patterns in Rif1-deficient cells and extending to patient samples.

RIF1 regulates replication origin activity and early replication timing in B cells

This study shows RIF1 regulates early replication timing and origin activity in B cells by interacting with MCM proteins, influencing gene replication without major effects on gene expression or genome organization.

A RIF1/KAP1-based toggle switch stabilises the identities of the inactive and active X chromosomes during X inactivation

The paper identifies RIF1 and KAP1 as key factors in establishing an asymmetric state during X inactivation by coordinating Tsix and Xist expression.

Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction

This study identifies RIF1 as a molecular hub that co-regulates nuclear organisation and replication timing through its interaction with PP1, revealing distinct functional requirements for these processes.