Andrea Cerase

Phase Separation Potential of Marsupial RSX RNA Reveals Convergent Evolution of X-Chromosome Inactivation Mechanisms

The paper identifies RSX interactors and shows they form phase-separation-prone networks, suggesting convergent evolution of XCI mechanisms through biophysical principles rather than sequence or structure.

CHD8 orchestrates chromatin landscapes during early female neuronal differentiation

This study investigates CHD8's role in female neuronal differentiation using multi-omics analysis, revealing its impact on chromatin structure and gene regulation in mouse models.

LBR nucleoplasmic domains regulate X-chromosome solubility and nuclear organization

This study shows that LBR nucleoplasmic domains regulate X-chromosome solubility and nuclear organization during neural differentiation in mouse cells.

A RIF1/KAP1-based toggle switch stabilises the identities of the inactive and active X chromosomes during X inactivation

The paper identifies RIF1 and KAP1 as key factors in establishing an asymmetric state during X inactivation by coordinating Tsix and Xist expression.

Xist lncRNA forms silencing granules that induce heterochromatin formation and repressive complexes recruitment by phase separation