Mechanistic insight into the dual phosphorylation of ERK1 and ERK2 by MEK1
Ying Sun, Cheng Peng, Shengjie Liu, Fayang Zhou, Gaoxingyu Huang, Jianbo Wang, Qi Hu
This study reveals the molecular mechanism of MEK1/2-catalyzed dual phosphorylation of ERK1/2 through cryo-EM structures and crosslinked complexes.
bioRxiv · Oct 15, 2026 · PreprintMolecular Biology