Ying Sun

This study reveals the molecular mechanism of MEK1/2-catalyzed dual phosphorylation of ERK1/2 through cryo-EM structures and crosslinked complexes.

The paper introduces REAL-SWIT, a generative framework for ultra-large virtual screening that efficiently explores chemical space by generating molecules with favorable docking scores.

This study uses an ABA-induced proximity system to reversibly control kinase signaling by recruiting phosphatases, revealing how phosphatases regulate oncogenic kinases like BCR::ABL1, BRAF(V600E), and MEK1.