Bioinformatics classification of the MgtE Mg2+ channel and de novo protein design for the stabilization of its novel subclass
Zhixuan Zhao, Kimiho Omae, Wataru Iwasaki, Ziyi Zhang, Fazhi Pan, Eun‐Jin Lee, Motoyuki Hattori
The paper identifies a novel subclass of MgtE Mg2+ channels and demonstrates that de novo protein design can stabilize and enable structural analysis of otherwise unstable homologs.
bioRxiv · May 26, 2025 · PreprintBiophysics