BiophysicsbioRxivPreprint
Cryo-EM reveals the structural basis of subtype-specific, noncompetitive inhibition of the human P2X3 receptor
Zhixuan Zhao, Dong-Ping Wang, Xin Zhang…·Motoyuki Hattori
The paper reports the cryo-EM structure of the human P2X3 receptor complexed with sivopixant, revealing subtype-specific allosteric inhibition mechanisms and structural basis for improved selectivity.