A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV infected cells
Jackson J. Peterson, Catherine A. Lewis, Samuel D. Burgos, Manickam Ashokkumar, Yinyan Xu, Allison A Rowley, Genevieve Clutton, Brian Richardson, Fei Zou, Jeremy M. Simon, David M. Margolis, Nilu P Goonetilleke, Edward P. Browne
The paper identifies HDAC inhibitors as agents that prevent HIV latency by maintaining viral expression and altering memory T cell phenotypes in infected cells.
Cell chemical biology · Dec 1, 2023Peer-reviewedMolecular Biology