Manickam Ashokkumar

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

The paper identifies TAF1 as a novel regulator of HIV latency through a chemical screen and genetic experiments, showing its role in maintaining viral transcriptional silence.

This study investigates how THC affects HIV-infected CD4 T cells using single-cell multiomic analysis, finding no effect on HIV reactivation but altered gene expression and chromatin accessibility.

This study identifies INTS12 knockout as a method to enhance HIV latency reversal by overcoming a transcriptional block, improving reactivation in CD4 T cells from HIV-positive individuals.

This paper identifies ETS1 as a regulator of HIV latency through a CRISPR screen and shows it has opposing roles in actively and latently infected CD4 T cells.

The paper identifies HDAC inhibitors as agents that prevent HIV latency by maintaining viral expression and altering memory T cell phenotypes in infected cells.