Glycan-dependent two-step cell adhesion mechanism of Tc toxins
Daniel Roderer, Felix Bröcker, Oleg Sitsel, Paulina Kapłonek, Franziska Leidreiter, Peter H. Seeberger, Stefan Raunser
This study identifies two glycans, heparins/heparan sulfates and Lewis antigens, as receptors for Tc toxins, revealing a two-step adhesion mechanism involving glycan binding to toxin subunits.
bioRxiv · Nov 29, 2019 · PreprintMolecular Biology